Role of Ion channels in male infertility

Abstract

Spermatogenesis is a complex and well-orchestrated process, in which spermatogonial stem cells undergo multiple rounds of DNA replication, meiosis, and cellular differentiation to produce mature spermatozoa. Sperm ion channels play an important role in maintaining sperm physiology and motility and fertilizing ability. Aberrant functioning of these ion channels may affect sperm functions like hyperactivation, capacitation, acrosome reaction, which will affect fertilization and subsequently may lead to infertility. The present review is focused on summarizing the role of sperm ion channels in male infertility.