Genetic polymorphisms in cytokine genes and urinary bladder cancer risk

  • Kirti Amresh Gautam King George's Medical University, Lucknow
  • ANAND NARAIN SRIVASTAVA Era’s Lucknow Medical College, Lucknow, India.
Keywords: urinary bladder cancer, cytokine genes polymorphisms, genetic polymorphisms, inflammation

Abstract

Urinary bladder cancer (UBC) is the ninth most common cancer worldwide. Cytokines have dual roles in cancer development. On one hand, they are involved in the activation of the immune response to control tumor growth. On the other hand, they may be involved in malignant transformation and tumor proliferation. Genetic variations of cytokines genes are thought to play an important role in individual’s susceptibility to any cancer and have emerged in recent years as significant determinants of cancer susceptibility and prognosis of cancer. In this review, the literature investigating the association between genetic polymorphisms of cytokine genes and risk of UBC are summarized. We have thoroughly reviewed the genetic polymorphism studies on IL-6, IL-4, TGF-β, TNF-α, PPARs and COX-2 genes in relation with UBC. Overall, it appears that genetic polymorphisms in the cytokine genes play an important role in determining susceptibility to UBC.

Author Biography

ANAND NARAIN SRIVASTAVA, Era’s Lucknow Medical College, Lucknow, India.

Professor,

Director Research,

Department of Pathology,

Era’s Lucknow Medical College,

Lucknow, India.

Published
2018-10-09
How to Cite
Gautam, K., & SRIVASTAVA, A. (2018). Genetic polymorphisms in cytokine genes and urinary bladder cancer risk. Polymorphism, 1, 31-41. Retrieved from https://peerpublishers.com/index.php/snp/article/view/9
Issue
Vol 1 (2018)
Section
Articles

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