Gene therapy in oral diseases-an ingisht

Abstract

The oral cavity is one of the most accessible areas for the clinical applications of gene therapy for various oral tissues. The idea of genetic engineering has become more exciting due to its advantages over other treatment modalities. The concept of transferring genes to tissues for clinical applications has been discussed for nearly half a century. With the advancement of research, genetic engineering has evolved with greater capability to determine etiopathogenesis, the processes, the disorders caused by gene alterations, the genes responsible and the actions in modulations of metabolic defects for the prevention and treatment of the pathologies. With the diversity of microorganisms and bacterial proliferation, it is difficult to control pathologies and homeostasis in the oral environment. Odontology has been employing technological resources in treatments through gene therapy and recombinant DNA to repair the genome, manipulating and substituting defective genes for healthy genes and providing a certain relief of the symptoms or the cure of oral diseases.

This review is presented to highlight various applications of gene therapy in dentistry in the areas such as salivary gland disorders, chronic pain, DNA vaccines, bone repair, implantology, head and neck cancer, orthodontic therapy, periodontal repair and tooth regrowth.