CYP1A1 rs4646903 T>C and rs1048943 A>G polymorphisms and the risk of colorectal cancer: An updated meta-analysis

CYP1A polymorphisms and colorectal cancer

Abstract

Aim: To find an association between the CYP1A1 rs4646903 T>C and rs1048943 A>G polymorphisms and the risk of colorectal cancer by compiling recent studies.

Methods: We performed a meta-analysis on recently published articles available on PubMed and Google search engines. After extensive search, a total of 33 publications were identified. Out of the 33 publications, a total of 18 recent studies were included in the meta-analysis, which contains 2190 cases and 3977 controls for rs4646903 T>C and 2300 cases and 3789 controls for rs1048943 A>G polymorphisms.

Results: The pooled analysis indicated that CYP1A1 rs4646903 T>C polymorphism is not a risk factor associated with colorectal cancer. The analysis of pooled data however, indicated a significant association between rs1048943 A>G and the risk of colorectal cancer [Over dominant model: OR=0.97, 95%CI (0.86-1.10); Dominant model: OR=0.97, 95% CI (0.86-1.09); Recessive model: OR=0.98, 95% CI (0.74-1.30); GA vs. AA: OR=0.97, 95% CI (0.86-1.10); GG vs. AA: OR=0.97, 95% CI (0.74-1.27)]. The comparison of the heterozygous genotypes has also shown the association. Further, alcohol and tobacco consumption increased colorectal cancer risk significantly. Our results are in line with the previous studies showing that CYP1A1 rs1048943 A>G polymorphism increases the risk of colorectal cancer and CYP1A1 rs4646903 T>C does not have any association with the risk of colorectal cancer.

Conclusion: Our study suggests that CYP1A1 rs1048943 A>G is a risk factor for the development of colorectal cancer. In addition to that, consumption of tobacco and alcohol also significantly increase the risk (p = 0.035). CYP1A1 rs4646903 T>C showed no significant association with colorectal cancer.